| Wk | Date & Time | Away | Home | TV | ||||
|---|---|---|---|---|---|---|---|---|
| 01 | Sat Feb 18 3:00PM ET |  | Vegas Vipers 20 | @ |  | Arlington Renegades 22 | ABC, ESPN+ | Game Summary |
| 01 | Sat Feb 18 8:30PM ET |  | Orlando Guardians 12 | @ |  | Houston Roughnecks 33 | ESPN / FX, ESPN+ | Game Summary |
| 01 | Sun Feb 19 3:00PM ET |  | St. Louis Battlehawks 18 | @ |  | San Antonio Brahmas 15 | ABC, ESPN+ | Game Summary |
| 01 | Sun Feb 19 8:00PM ET |  | Seattle Sea Dragons 18 | @ |  | D.C. Defenders 22 | ESPN, ESPN+ | Game Summary |
| 02 | Thu Feb 23 9:00PM ET | | St. Louis Battlehawks 20 | @ | | Seattle Sea Dragons 18 | FX, ESPN+ | Game Summary |
| 02 | Sat Feb 25 7:00PM ET | | D.C. Defenders 18 | @ | | Vegas Vipers 6 | FX, ESPN+ | Game Summary |
| 02 | Sun Feb 26 4:00PM ET | | San Antonio Brahmas 30 | @ | | Orlando Guardians 12 | ESPN, ESPN+ | Game Summary |
| 02 | Sun Feb 26 7:00PM ET | | Arlington Renegades 14 | @ | | Houston Roughnecks 23 | ESPN2, ESPN+ | Game Summary |
| 03 | Sat Mar 4 7:00PM ET | | Seattle Sea Dragons 30 | @ | | Vegas Vipers 26 | FX, ESPN+ | Game Summary |
| 03 | Sun Mar 5 1:00PM ET | | St. Louis Battlehawks 28 | @ | | D.C. Defenders 34 | FX, ESPN+ | Game Summary |
| 03 | Sun Mar 5 4:00PM ET | | Orlando Guardians 9 | @ | | Arlington Renegades 10 | FX, ESPN+ | Game Summary |
| 03 | Sun Mar 5 8:00PM ET | | San Antonio Brahmas 13 | @ | | Houston Roughnecks 22 | ESPN2, ESPN+ | Game Summary |
| 04 | Sat Mar 11 7:00PM ET | | Houston Roughnecks 44 | @ | | Orlando Guardians 16 | FX, ESPN+ | Game Summary |
| 04 | Sat Mar 11 10:00PM ET | | San Antonio Brahmas 6 | @ | | Seattle Sea Dragons 15 | FX, ESPN+ | Game Summary |
| 04 | Sun Mar 12 4:00PM ET | | Arlington Renegades 11 | @ | | St. Louis Battlehawks 24 | ESPN2, ESPN+ | Game Summary |
| 04 | Sun Mar 12 7:00PM ET | | Vegas Vipers 18 | @ | | D.C. Defenders 32 | ESPN2, ESPN+ | Game Summary |
| 05 | Thu Mar 16 10:30PM ET | | Houston Roughnecks 14 | @ | | Seattle Sea Dragons 21 | ESPN, ESPN+ | Game Summary |
| 05 | Sat Mar 18 7:00PM ET | | D.C. Defenders 28 | @ | | St. Louis Battlehawks 20 | FX, ESPN+ | Game Summary |
| 05 | Sat Mar 18 10:00PM ET | | Orlando Guardians 32 | @ | | Vegas Vipers 35 | FX, ESPN+ | Game Summary |
| 05 | Sun Mar 19 9:00PM ET | | Arlington Renegades 12 | @ | | San Antonio Brahmas 10 | ESPN2, ESPN+ | Game Summary |
| 06 | Sat Mar 25 1:00PM ET | | Seattle Sea Dragons 26 | @ | | Orlando Guardians 19 | ABC, ESPN+ | Game Summary |
| 06 | Sat Mar 25 7:00PM ET | | St. Louis Battlehawks 29 | @ | | Vegas Vipers 6 | FX, ESPN+ | Game Summary |
| 06 | Sun Mar 26 3:00PM ET | | San Antonio Brahmas 15 | @ | | Arlington Renegades 9 | ABC, ESPN+ | Game Summary |
| 06 | Mon Mar 27 7:00PM ET | | Houston Roughnecks 26 | @ | | D.C. Defenders 37 | ESPN2, ESPN+ | Game Summary |
| 07 | Fri Mar 31 7:00PM ET | | Seattle Sea Dragons 24 | @ | | Arlington Renegades 15 | FX, ESPN+ | Game Summary |
| 07 | Sat Apr 1 3:00PM ET | | San Antonio Brahmas 12 | @ | | Vegas Vipers 26 | ESPN2, ESPN+ | Game Summary |
| 07 | Sat Apr 1 6:00PM ET | | D.C. Defenders 36 | @ | | Orlando Guardians 37 | ESPN, ESPN+ | Game Summary |
| 07 | Sun Apr 2 2:00PM ET | | St. Louis Battlehawks 24 | @ | | Houston Roughnecks 15 | ESPN, ESPN+ | Game Summary |
| 08 | Sat Apr 8 1:00PM ET | | Vegas Vipers 17 | @ | | St. Louis Battlehawks 21 | ESPN, ESPN+ | Game Summary |
| 08 | Sat Apr 8 4:00PM ET | | Arlington Renegades 18 | @ | | Orlando Guardians 16 | ESPN, ESPN+ | Game Summary |
| 08 | Sun Apr 9 3:00PM ET | | Houston Roughnecks 17 | @ | | San Antonio Brahmas 15 | ABC, ESPN+ | Game Summary |
| 08 | Sun Apr 9 7:00PM ET | | D.C. Defenders 34 | @ | | Seattle Sea Dragons 33 | ESPN2, ESPN+ | Game Summary |
| 09 | Sat Apr 15 12:30PM ET | | Vegas Vipers 21 | @ | | Houston Roughnecks 28 | ABC, ESPN+ | Game Summary |
| 09 | Sat Apr 15 7:00PM ET | | Orlando Guardians 23 | @ | | San Antonio Brahmas 25 | ESPN2, ESPN+ | Game Summary |
| 09 | Sun Apr 16 12:00PM ET | | Arlington Renegades 26 | @ | | D.C. Defenders 28 | ESPN, ESPN+ | Game Summary |
| 09 | Sun Apr 16 3:00PM ET | | Seattle Sea Dragons 30 | @ | | St. Louis Battlehawks 12 | ESPN, ESPN+ | Game Summary |
| 10 | Sat Apr 22 12:00PM ET | | Orlando Guardians 28 | @ | | St. Louis Battlehawks 53 | ESPN, ESPN+ | Game Summary |
| 10 | Sat Apr 22 3:00PM ET | | D.C. Defenders 29 | @ | | San Antonio Brahmas 28 | ABC, ESPN+ | Game Summary |
| 10 | Sun Apr 23 3:00PM ET | | Houston Roughnecks 25 | @ | | Arlington Renegades 9 | ESPN, ESPN+ | Game Summary |
| 10 | Sun Apr 23 7:00PM ET | | Vegas Vipers 9 | @ | | Seattle Sea Dragons 28 | ESPN2, ESPN+ | Game Summary |
| 11 | Sat Apr 29 7:00PM ET | | Arlington Renegades 26 | @ | | Houston Roughnecks 11 | ESPN, ESPN+ | Game Summary |
| 11 | Sun Apr 30 3:00PM ET | | Seattle Sea Dragons 21 | @ | | D.C. Defenders 37 | ESPN, ESPN+ | Game Summary |
| 12 | Sat May 13 8:00PM ET | | D.C. Defenders 26 | vs | | Arlington Renegades 35 | ABC, ESPN+ | Game Summary |
